International Committee of the Red Cross and Red Crescent Societies
Action for the most vulnerable in over 175 countries worldwide. "...an impartial, neutral and independent organization whose exclusively humanitarian mission is to protect the lives and dignity of victims of war and internal violence and to provide them with assistance. It directs and coordinates the international relief activities conducted by the Movement in situations of conflict. It also endeavours to prevent suffering by promoting and strengthening humanitarian law and universal humanitarian principles.
International Red Cross and Red Crescent Donate You can specify which programs of the Red Cross you to wish you wish to donate.
Official Donation Sites of American Red Csross

Doctors Without Borders/Medecins Sans Frontieres is "an international independent medical humanitarian organization that delivers emergency aid to people affected by armed conflict, epidemics, natural and man-made disasters, and exclusion from health care in nearly 70 countries.

Each year, MSF volunteer doctors, nurses, logisticians, water-and-sanitation experts, administrators, and other medical and non-medical professionals depart on more than 3,400 aid missions. They work alongside more than 16,000 locally hired staff to provide medical care.

In emergencies and their aftermath, MSF provides health care, rehabilitates and runs hospitals and clinics, performs surgery, battles epidemics, carries out vaccination campaigns, operates feeding centers for malnourished children, and offers mental health care. When needed, MSF also constructs wells and dispenses clean drinking water, and provides shelter materials like blankets and plastic sheeting."

Also longer-term programs provide medical and psychological care.
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"Oxfam works with communities, allies and partner organizations, undertaking long-term development, emergency work, research and campaigning for a fairer world.

Oxfam works on a broad range of issues, including trade, conflict, debt and aid, and education."

Oxfam International seeks increased worldwide public understanding that economic and social justice are crucial to sustainable development.
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Since 1991, WER has been a leader in promoting the responsible and ethical use of “gifts-in-kind” at our own projects worldwide, as well as projects we share with other outreaches."

U.S. Programs
The heart of Feed The Children's U.S. program is distributing food to needy families. To do this, we work closely with caring corporate partners that donate surplus food and other supplies, as well as with individual donors who help defray the cost of transporting the product donations."

International
"Since 1979, we have provided food, clothing, medical assistance and educational opportunities to those in need in more than 115 nations around the world. Through schools, orphanages and church-related programs, Feed The Children touches the lives of thousands of children overseas every day. We also provide financial assistance to orphanages, schools and other charitable groups in these regions."
Donate in many different ways - see the main page.

"WFP works to stop Hunger: food aid breaks the poverty cycle Food aid can break the cycle of poverty. Innovative food aid projects, which play an integral part in WFP's relief & rehabilitation and development operations, allow the weak and poor, including people made homeless by natural disasters, returning refugees, HIV/AIDS orphans and jobless mothers, to stop worrying about their next meal and build a sustainable future."

"WFP relies entirely on voluntary contributions to finance its humanitarian and development projects. None of the average 90 million people in more than 80 countries who eat WFP food each year could do so without the generosity of our donors.

Donations are made either as cash, food such as flour, beans, oil, salt and sugar, or the basic items necessary to grow, store and cook food - kitchen utensils, agricultural tools, warehouses. " "More than 60 governments fund WFP's humanitarian and development activities. They are the Programme's major source of funding. WFP receives no dues or portions of the UN assessed contributions."
Contributions can be earmarked for specific programs worldwide.
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The AmeriCares Model For over two decades, the success of AmeriCares has been characterized by timely response, meaningful impact, high integrity and intense passion for the work. To deliver medicine, relief supplies and health care to the needy, AmeriCares has developed a platform based on strategic partnerships, high-efficiency and tight auditing procedures.

Since its founding, AmeriCares has provided more than $4.0 billion of aid in more than 137 countries. To accomplish these results, AmeriCares assembles product donations from the private sector, determines the most urgent needs and solicits the funding to send the aid via airlift or ocean cargo to health and welfare professionals in the indigent locations. "

"Response to Hurricane Katrina, Ongoing humanitarian aid in Sudan and Chad, AmeriCares Free Clinics Plans to Expand in Bridgeport, CT, Report from Indonesia by the Head of AmeriCares Tsunami Relief Program, AmeriCares receives Charity Navigator's 4-star rating for the fourth consecutive year, AmeriCares continues to respond to flooding in India, Aid Reaching Children in Niger
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In the coming months we will share with you innovative solutions implemented by Ashoka’s network of 1600 leading social entrepreneurs in 60 countries, and the work Ashoka is doing to build group entrepreneurship around the world. We will also offer you the opportunity to help Ashoka create impact through investment in systems change.

This year 2,000,000 people will be sold, kidnapped, and coerced into slavery -- almost half of whom are children. These victims are subjected to the worst of humanity -- sexual violence, horrific living conditions, threats against their families, and treacherous workplaces.

Ashoka Fellow Sunita Krrishnan is in India, protecting and rehabilitating sexually trafficked children; Derek Ellerman in the US, is building a citizen movement to end sex trafficking networks; and Kailash Satyarthia in India is fighting the use of child labor. All are creating a new way to combat human trafficking that focuses on ending the problem.
Donate - Investment in Ashoka